Research Progress of 1,3,5-Triazinanes in the Synthesis of Nitrogen-Containing Heterocycles
Jiantao Zhang, Peng Zhou, Duoduo Xiao, Weibing Liu
Abstract
1,3,5-Triazinanes are an important class of synthons, which could be regarded as the equivalent of formaldehyde imines in constructing various nitrogen-containing heterocyclic skeletons. In recent years, 1,3,5-triazinanes have attracted much attention in the construction of nitrogen-containing heterocyclic compounds. Based on this, the participation of 1,3,5-triazinanes as diatomic, triatomic and four-atom synthons in [2n], [3n], [4n] cycloaddition reactions to construct nitrogen-containing heterocyclic compounds is systematically summarized. Its applications in cycloaddition, heterocyclic chemistry and pharmaceutical chemistry are also summarized. Moreover, the development of 1,3,5-triazinanes in the construction of nitrogen-containing heterocyclic skeletons and their future applications are also prospected.