MiR-182-5p Mediated by Exosomes Derived From Bone Marrow Mesenchymal Stem Cell Attenuates Inflammatory Responses by Targeting TLR4 in a Mouse Model of Myocardial Infraction
Chuang Sun, Wei Li, Yanhong Li, Jian Chen, Huixian An, Guangwei Zeng, Tingting Wang, Yazhou Guo, Changying Wang
Abstract
-stimulated NMVMs enhanced cell viability and suppressed the expression of inflammatory cytokines. In addition, they promoted heart function, suppressed inflammatory responses, and de-activated TLR4/NF-κB signaling pathway in MI mice. In conclusion, miR-182-5p transferred by the exosomes derived from BM-MSCs protected against MI-induced impairments by targeting TLR4.
Topics & Concepts
Mesenchymal stem cellMicrovesiclesExosomeTLR4MedicineStem cellBone marrowCell biologymicroRNACancer researchInflammationImmunologyBiologyPathologyBiochemistryGeneExtracellular vesicles in diseaseMicroRNA in disease regulationCircular RNAs in diseases