Active aldehydes accelerate CD8+ T cell exhaustion by metabolic alteration in the tumor microenvironment
Yasuharu Haku, Koji Kitaoka, Koki Ichimaru, T Hirano, Jun Wang, Kazuhiro Sonomura, Asuka Maruo, Shuhei Hirose, Yanru Wang, Katsuhiro Ito, Tomohiro Kozuki, Keiko Yurimoto, Mai Kiyono, Hidetaka Kosako, T. Menju, Hiroshi Date, Takashi Kobayashi, Koichi Omori, Tomonori Yaguchi, Tasuku Honjo, Kenji Chamoto
Topics & Concepts
GlycolysisChemistryT cellMitochondrionAnaerobic glycolysisMetabolic pathwayCell biologyBiochemistryTumor microenvironmentBeta oxidationCellMetabolismCell growthEnzymeCitric acid cycleAcroleinLipid peroxidationOxidative phosphorylationLipid metabolismCancer researchFatty acid metabolismCytotoxic T cellProgrammed cell deathCytosolCell cycleAntioxidant Activity and Oxidative StressCancer Immunotherapy and BiomarkersAlcohol Consumption and Health Effects