<i>n</i> -Alkanes to <i>n</i> -alcohols: Formal primary C─H bond hydroxymethylation via quadruple relay catalysis
Xinxin Tang, Lan Gan, Xin Zhang, Zheng Huang
Abstract
-alkane primary C─H bond hydroxymethylation. This one-pot multicatalysis system is composed of Ir-catalyzed alkane dehydrogenation, Rh-catalyzed olefin isomerization and hydroformylation, and Ru-catalyzed aldehyde hydrogenation. This system is further applied to synthesis of α,ω-diols from simple α-olefins through terminal-selective hydroxymethylation of silyl alkanes.
Topics & Concepts
CatalysisDehydrogenationAlkaneHydroformylationChemistryOlefin fiberIsomerizationAldehydePrimary (astronomy)Combinatorial chemistryOrganic chemistryRhodiumPhysicsAstronomyAsymmetric Hydrogenation and CatalysisCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions