Plasma and Interstitial Fluid Pharmacokinetics of Prophylactic Cefazolin in Elective Bariatric Surgery Patients
Rochelle Ryan, Dwane Jackson, George Hopkins, Victoria Eley, Rebecca Christensen, André van Zundert, Steven C. Wallis, Jeffrey Lipman, Suzanne L. Parker, Jason A. Roberts
Abstract
Guidelines for surgical prophylactic dosing of cefazolin in bariatric surgery vary in terms of recommended dose. This study aimed to describe the plasma and interstitial fluid (ISF) cefazolin pharmacokinetics in patients undergoing bariatric surgery and to determine an optimum dosing regimen.
Topics & Concepts
CefazolinMedicineDosingPharmacokineticsRegimenSurgeryPlasma concentrationAnesthesiaPlasma levelsAntibioticsInternal medicineChemistryBiochemistryAnesthesia and Pain ManagementAntibiotics Pharmacokinetics and EfficacyAnesthesia and Sedative Agents