Wedelolactone activates the PI3K/AKT/NRF2 and SLC7A11/GPX4 signalling pathways to alleviate oxidative stress and ferroptosis and improve sepsis-induced liver injury
Yanping Yin, Fei Mu, Lulu Zhang, Jinyi Zhao, Rui Gong, Yanli Yin, Lingling Zheng, Yang Du, Fuxing Jin, Jingwen Wang
Topics & Concepts
Oxidative stressPI3K/AKT/mTOR pathwaySepsisProtein kinase BLiver injuryPharmacologyMedicineGPX4Signal transductionChemistryImmunologyBiochemistryInternal medicineCatalaseGlutathione peroxidaseFerroptosis and cancer prognosisImmune cells in cancerNatural Compounds in Disease Treatment