Recent Advances in Palladium-Catalyzed Isocyanide Insertions
Jurriën W. Collet, Thomas R. Roose, Bram Weijers, Bert U. W. Maes, Eelco Ruijter, Romano V. A. Orrù
Abstract
Isocyanides have long been known as versatile chemical reagents in organic synthesis. Their ambivalent nature also allows them to function as a CO-substitute in palladium-catalyzed cross couplings. Over the past decades, isocyanides have emerged as practical and versatile C1 building blocks, whose inherent N-substitution allows for the rapid incorporation of nitrogeneous fragments in a wide variety of products. Recent developments in palladium catalyzed isocyanide insertion reactions have significantly expanded the scope and applicability of these imidoylative cross-couplings. This review highlights the advances made in this field over the past eight years.