Reversible lysine-targeted probes reveal residence time-based kinase selectivity
Tangpo Yang, Adolfo Cuesta, Xiaobo Wan, Gregory B. Craven, Brad Hirakawa, Penney Khamphavong, Jeffrey R. May, John C. Kath, John D. Lapek, Sherry Niessen, Alma L. Burlingame, Jordan D. Carelli, Jack Taunton
Topics & Concepts
KinaseLysineDruggabilityCysteineCovalent bondChemistryBiochemistryProtein kinase ASelectivityEnzymeAmino acidCatalysisGeneOrganic chemistryClick Chemistry and ApplicationsProtein Degradation and InhibitorsChemical Synthesis and Analysis