Demonstration of a Common DPhe <sup>7</sup> to DNal(2′) <sup>7</sup> Peptide Ligand Antagonist Switch for Melanocortin-3 and Melanocortin-4 Receptors Identifies the Systematic Mischaracterization of the Pharmacological Properties of Melanocortin Peptides
Luis E. Gimenez, Terry A. Noblin, Savannah Y. Williams, Satarupa Mullick Bagchi, Renlei Ji, Ya‐Xiong Tao, Claus Jeppesen, Kilian W. Conde‐Frieboes, Tomi K. Sawyer, Paolo Grieco, Roger D. Cone
Abstract
-containing peptides date back to 2003; thus, our analysis suggests that systematic mischaracterization of the pharmacological properties of melanocortin peptides occurred.
Topics & Concepts
MelanocortinMelanocortin 3 receptorMelanocortin receptorAgonistReceptorAlaninePeptideChemistryMelanocortin 1 receptorHEK 293 cellsMelanocortin 4 receptorResidue (chemistry)TransfectionBiochemistryMolecular biologyPeptide sequenceStereochemistryBiologyAmino acidGenePhenotypeRegulation of Appetite and ObesityBiochemical Analysis and Sensing Techniquesmelanin and skin pigmentation