Long non-coding RNA tumor protein 53 target gene 1 promotes cervical cancer development via regulating microRNA-33a-5p to target forkhead box K2
Dan Liao, Xiaomei Liu, Xiuying Yuan, Poling Feng, Zhiwei Ouyang, Yanyan Liu, Cuifen Li
Abstract
. TP53TG1 accelerates the CC development via regulating miR-33a-5p to target FOXK2 with the involvement of PI3K/AKT/mTOR signaling pathway. This study provides novel theory basis and distinct therapeutic targets for CC treatment.
Topics & Concepts
PI3K/AKT/mTOR pathwayBiologyProtein kinase BmicroRNACarcinogenesisCancer researchKinaseSignal transductionCell biologyCancerGeneGeneticsCancer-related molecular mechanisms researchMicroRNA in disease regulationCircular RNAs in diseases