Refractory Hyperlactatemia and Hypoglycemia in an Adult with Non-Hodgkin’s Lymphoma: A Case Report and Review of the Warburg Effect
Zainab Al Maqrashi, Mary Sedarous, Avinash Pandey, Catherine Ross, Ahraaz Wyne
Abstract
Lactate is a byproduct of anaerobic glycolysis, and hyperlactatemia is commonly seen in critically ill patients. We report a case of an elderly male presenting with undifferentiated constitutional symptoms, anemia, thrombocytopenia, severe lactic acidosis, refractory hypoglycemia, and a newly detected abdominal mass. A dedicated workup ruled out infectious etiologies and revealed metastatic non-Hodgkin's lymphoma. This study explores etiologies of type B lactic acidosis in oncology patients, with a focus on Warburg's effect, and its potential for prognostication.
Topics & Concepts
HyperlactatemiaMedicineLactic acidosisHypoglycemiaEtiologyLymphomaRefractory (planetary science)Anaerobic exerciseMetabolic acidosisGastroenterologyIntensive care medicineInternal medicineInsulinPhysiologyAstrobiologyPhysicsCancer, Hypoxia, and MetabolismHyperglycemia and glycemic control in critically ill and hospitalized patientsNeuroblastoma Research and Treatments