Rapid Access to <i>N</i>-Protected Sulfonimidoyl Fluorides: Divergent Synthesis of Sulfonamides and Sulfonimidamides
Yongan Liu, Qijun Pan, Xiaojun Hu, Yong Guo, Qing‐Yun Chen, Chao Liu
Abstract
Herein we report a practical and efficient copper-catalyzed approach for the conversion of various arenediazonium salts to the corresponding N-protected sulfonimidoyl fluorides. This operationally simple protocol tolerates a wide range of functional groups and can be applied to the late-stage modification of complex bioactive molecules. Furthermore, pharmaceutically important primary sulfonamides and sulfonimidamides derived from these valuable N-protected sulfonimidoyl fluoride units were prepared in minimal synthetic steps.
Topics & Concepts
ChemistryCombinatorial chemistryFluoridePrimary (astronomy)MoleculeCatalysisSulfonamideOrganic chemistryInorganic chemistryPhysicsAstronomySynthesis and Catalytic ReactionsSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization Methods