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Pharmacological modulation of the PI3K/AKT/GSK3β axis: a new frontier in Alzheimer’s disease treatment

Saad Misfer Alqahtani, Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb, Ali K. Albuhadily, Mustafa M Shokr, Αθανάσιος Αλεξίου, Marios Papadakis, Gaber El-Saber Batiha

2025Inflammopharmacology8 citationsDOI

Topics & Concepts

NeuroprotectionGSK-3Signal transductionNeuroscienceMedicineKinasePathogenesisHyperactivationInsulin receptorNeurodegenerationProtein kinase ADiseaseBioinformaticsTau proteinPharmacologyGSK3BAlzheimer's diseaseNeurologyBiologyPI3K/AKT/mTOR pathwayCognitive declineCell signalingIntracellularPhosphatidylinositolLong-term potentiationLipid signalingInsulin resistanceAlzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchPI3K/AKT/mTOR signaling in cancer
Pharmacological modulation of the PI3K/AKT/GSK3β axis: a new frontier in Alzheimer’s disease treatment | Litcius