Serotonin/HTR1E signaling blocks chronic stress-promoted progression of ovarian cancer
Xuan Qin, Jia Li, Shiqing Wang, Jianying Lv, Fangkun Luan, Yanhua Liu, Yanan Chen, Xiaosu Chen, Yujia Zhao, Jingjin Zhu, Yongjun Piao, Wenwen Zhang, Yi Shi, Rong Xiang, Pengpeng Qu, Longlong Wang
Abstract
We discovered the essential role of serotonin/HTR1E signaling in preventing the chronic psychological stress-promoted progression of OC, suggesting the potential therapeutic value of the HTR1E specific agonist and the SRC inhibitor for OC patients who are suffering from psychological stress.
Topics & Concepts
CancerChronic stressCancer researchOvarian cancerMedicineSerotoninOncologyInternal medicineEndocrinologyBiologyBioinformaticsReceptorCancer, Stress, Anesthesia, and Immune ResponseStress Responses and CortisolNeuroendocrine regulation and behavior