oFlowSeq: a quantitative approach to identify protein coding mutations affecting cell type enrichment using mosaic CRISPR-Cas9 edited cerebral organoids
Pepper Dawes, Liam F. Murray, Meagan N. Olson, Nathaniel Barton, Molly Smullen, Madhusoodhanan Suresh, Guang Yan, Yucheng Zhang, Aria Fernandez-Fontaine, Jay English, Mohammed Uddin, ChangHui Pak, George M. Church, Yingleong Chan, Elaine T. Lim
Topics & Concepts
CRISPRBiologyLocus (genetics)IndelGeneticsGeneComputational biologyOrganoidCell typeHuman geneticsCas9GenotypeCellSingle-nucleotide polymorphismCRISPR and Genetic EngineeringSingle-cell and spatial transcriptomicsPluripotent Stem Cells Research