<i>In situ</i> detection of hydroxyl radicals in mitochondrial oxidative stress with a nanopipette electrode
Wenting Chen, Shushu Ding, Jiaren Wu, Guoyue Shi, Anwei Zhu
Abstract
A novel nanopipette electrode was facilely constructed for the detection of ˙OH based on the inner surface wettability. The nanopipettes with excellent analytical performance were empolyed for in situ detection of ˙OH changes induced by mitochondrial oxidative stress and further utilized to study the association of ˙OH with Alzheimer's disease.
Topics & Concepts
In situRadicalOxidative stressChemistryElectrodeOxidative phosphorylationPhotochemistryOrganic chemistryBiochemistryPhysical chemistryElectrochemical Analysis and ApplicationsNanopore and Nanochannel Transport StudiesAnalytical Chemistry and Sensors