Advances in understanding the role of mitochondria in renal ischemia–reperfusion injury
Huimeng Li, Xiangbo Wang, Danfang Deng, Shenhui Lv, Lili Huang, Xiaoqin Wang, Xiaoqin Wang, Xiaoqin Wang
Abstract
Renal ischemia-reperfusion injury (RIRI) is a major cause of acute kidney failure. Recent studies have shown that RIRI mechanism is closely related to abnormal mitochondrial biogenesis, fusion, fission, and autophagy. Maintaining normal mitochondrial function is essential for RIRI treatment. Therefore, it is important to explore molecular mechanisms of RIRI and relevant therapeutic targets. This review describes the role of mitochondria in RIRI and summarises information about potential drugs that regulate mitochondrial function, with the aim of providing ideas for clinical targeting of mitochondria to prevent and treat RIRI.
Topics & Concepts
MitochondrionMitochondrial fissionMedicineAutophagyMitochondrial biogenesisMechanism (biology)Function (biology)Reperfusion injurymitochondrial fusionIschemiaCell biologyMitochondrial DNABioinformaticsPharmacologyBiologyApoptosisInternal medicineGeneticsGenePhilosophyEpistemologyMitochondrial Function and PathologyMetabolism and Genetic DisordersAcute Kidney Injury Research