Knockdown of <i>Foxg1</i> in Sox9+ supporting cells increases the trans-differentiation of supporting cells into hair cells in the neonatal mouse utricle
Yuan Zhang, Shasha Zhang, Zhonghong Zhang, Ying Dong, Xiangyu Ma, Ruiying Qiang, Yin Chen, Xia Gao, Chunjie Zhao, Fangyi Chen, Shuangba He, Renjie Chai
Abstract
cKD in utricular SCs may promote HC regeneration by inducing trans-differentiation of SCs. This research therefore provides theoretical basis for the effects of Foxg1 in trans-differentiation of SCs and regeneration of HCs in the mouse utricle.
Topics & Concepts
Gene knockdownUtricleSOX9Cell biologyBiologyAndrologyAnatomyMedicineGeneticsApoptosisGeneTranscription factorInner earHearing, Cochlea, Tinnitus, GeneticsCancer-related molecular mechanisms researchMicroRNA in disease regulation