Management of Multiple Myeloma: A Review for General Practitioners in Oncology
Bethany Monteith, Irwindeep Sandhu, Ann Lee
Abstract
Multiple myeloma (MM) is a malignant clonal plasma cell disorder in the bone marrow and is the second-most common hematologic malignancy in adults. Although patients with MM have a moderate life expectancy, it remains a heterogeneous disease that often requires multiple lines of chemotherapy for durable control and long-term survival. This review outlines current management strategies for both transplant-eligible and transplant-ineligible patients as well as for relapsed and refractory disease. Advances in drug therapies have widened management options and improved survival. In this paper, we also discuss implications for special populations and survivorship care.
Topics & Concepts
MedicineMultiple myelomaLife expectancyMalignancySurvivorship curveDiseaseOncologyHematologic malignancyInternal medicineIntensive care medicineChemotherapyBone marrowCancerPopulationEnvironmental healthMultiple Myeloma Research and TreatmentsProtein Degradation and InhibitorsPeptidase Inhibition and Analysis