Chalcone derivatives as promising antifoulants: Molecular optimization, bioactivity evaluation and performance in coatings
Daniela Pereira, Andreia Palmeira, Érica Lima, Vı́tor Vasconcelos, Madalena Pinto, Marta Correia-da-Silva, Joana R. Almeida, Honorina Cidade
Abstract
= 6.75 µM). Regarding the structure-activity relationship, the overall results demonstrate that the substitution of the chalcone of the lead compound 1 by a dihydrochalcone scaffold resulted in an optimized potency against the settlement of mussel larvae. Marine polyurethane (PU)-based coatings containing the best performed compound concerning anti-settlement activity (dihydrochalcone 27) were prepared, and mussel larvae adherence was reduced compared to control PU coatings.
Topics & Concepts
ChalconeBiochemical engineeringChemistryCombinatorial chemistryNanotechnologyEnvironmental scienceMaterials scienceEnvironmental chemistryOrganic chemistryEngineeringMarine Biology and Environmental ChemistryMarine Sponges and Natural ProductsCholinesterase and Neurodegenerative Diseases