The SARS-CoV-2 receptor-binding domain preferentially recognizes blood group A
Shang‐Chuen Wu, Connie M. Arthur, Jianmei Wang, Hans Verkerke, Cassandra D. Josephson, Daniel Kalman, John D. Roback, Richard D. Cummings, Sean R. Stowell
Abstract
Key Points The RBD of SARS-CoV-2 shares sequence similarity with an ancient lectin family known to bind blood group antigens. SARS-CoV-2 RBD binds the blood group A expressed on respiratory epithelial cells, directly linking blood group A and SARS-CoV-2.
Topics & Concepts
Blood group antigensSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)ReceptorBiologyAntigenSequence (biology)Coronavirus disease 2019 (COVID-19)2019-20 coronavirus outbreakVirologyImmunologyMolecular biologyCell biologyGeneticsMedicineInternal medicineDiseaseInfectious disease (medical specialty)OutbreakBlood groups and transfusionSARS-CoV-2 and COVID-19 ResearchErythrocyte Function and Pathophysiology