SIRT5 Represses Neurotrophic Pathways and Aβ Production in Alzheimer’s Disease by Targeting Autophagy
Shanshan Wu, Yafen Wei, Jingxin Li, Yan Bai, Ping Yin, Shun Wang
Abstract
through activating autophagy. We presented ectopic expression of SIRT5 as a promising therapeutic approach for AD.
Topics & Concepts
AutophagyMicrogliaOxidative stressMorris water navigation taskGenetically modified mouseReactive oxygen speciesCell biologyNeurodegenerationBECN1Neurotrophic factorsEctopic expressionTransgeneInflammationChemistryBiologyEndocrinologyInternal medicineImmunologyMedicineBiochemistryApoptosisDiseaseHippocampal formationReceptorGeneSirtuins and Resveratrol in MedicineAutophagy in Disease and TherapyAlzheimer's disease research and treatments