Rheological investigation of collagen, fibrinogen, and thrombin solutions for drop-on-demand 3D bioprinting
Hemanth Gudapati, Daniele Parisi, Ralph H. Colby, İbrahim T. Özbolat
Abstract
. The addition of a non-ionic surfactant, such as polysorbate 80 (PS80) in small amounts between 0.001 and 0.1 v/v%, prevents the formation of the interfacial layer, allowing the estimation of true bulk viscosity of the solutions. The estimation of viscosity not only helps in identifying those protein solutions that are potentially printable with drop-on-demand (DOD) inkjet printing but also detects inconsistencies in flow behavior among the batches.
Topics & Concepts
FibrinogenThrombinRheologyDrop (telecommunication)Aqueous solution3D bioprintingMaterials scienceChemistryCoagulationChemical engineeringTissue engineeringComposite materialBiomedical engineeringBiochemistryOrganic chemistryEngineeringMechanical engineeringImmunologyPsychiatryPlateletPsychologyBiology3D Printing in Biomedical ResearchInnovative Microfluidic and Catalytic Techniques InnovationAdditive Manufacturing and 3D Printing Technologies