Diallyl Biphenyl-Type Neolignans Have a Pharmacophore of PPARα/γ Dual Modulators
Yujia Han, Jingjing Liu, Sungjin Ahn, Seungchan An, Hyejin Ko, Jeayoung C. Shin, Sun Hee Jin, Min Won Ki, So Hun Lee, Kang Hyuk Lee, Song Seok Shin, Won Jun Choi, Minsoo Noh
Abstract
-methylhonokiol were elucidated as PPARα and PPARγ dual modulators. Diallyl biphenyl-type neolignans affected the transcription of lipid metabolism-associated genes in a different way compared to those of specific PPAR ligands. The diallyl biphenyl-type neolignan structure provides a novel pharmacophore of PPARα/γ dual modulators, which may have unique therapeutic potentials in diverse metabolic diseases.
Topics & Concepts
HonokiolMagnololPharmacophoreChemistryPharmacologyMagnolia officinalisBiochemistryBiologyMedicineAlternative medicineTraditional Chinese medicinePathologyMagnolia and Illicium researchPeroxisome Proliferator-Activated ReceptorsSignaling Pathways in Disease