Oncogenic Mutations and Gene Fusions in CD30-Positive Lymphoproliferations and Clonally Related Mycosis Fungoides Occurring in the Same Patients
Marion Wobser, Sabine Roth, Silke Appenzeller, Hermann Kneitz, Matthias Goebeler, Eva Geissinger, Andreas Rosenwald, Katja Maurus
Abstract
mutations exclusively occurred in lesions of CD30-positive LPD in one patient. CD30-positive LPD and MF may share genetic events when occurring within the same patients. Constitutive activation of the Jak/signal transducer and activator of transcription signaling pathway may play a central role in the molecular pathogenesis of both entities.
Topics & Concepts
STAT proteinCD30BiologyMycosis fungoidesCancer researchKRASGeneMutationSTAT3LymphomaGeneticsImmunologyTumor cellsCutaneous lymphoproliferative disorders researchLymphoma Diagnosis and TreatmentFungal Infections and Studies