CMV and HSV Pneumonia After Immunosuppressive Agents for Treatment of Cytokine Release Syndrome Due to Chimeric Antigen Receptor–modified T (CAR-T)-Cell Immunotherapy
Madeleine R. Heldman, Jimmy Ma, Jordan Gauthier, Riley A. O’Hara, Andrew J. Cowan, Leah M. Yoke, L L So, Elizabeth Gulleen, Elizabeth R. Duke, Catherine Liu, Cameron J. Turtle, Joshua A. Hill
Abstract
Pneumonia due to cytomegalovirus and herpes simplex virus-1 caused substantial morbidity after hematopoietic cell transplantation before the institution of preventative approaches. End-organ disease from herpesviruses is poorly described after chimeric antigen receptor-modified T-cell immunotherapy. We report 2 cases of cytomegalovirus pneumonia and 1 case of herpes simplex virus-1 gingivostomatitis, esophagitis, and pneumonia after chimeric antigen receptor-modified T-cell immunotherapy for the treatment of hematologic malignancies.
Topics & Concepts
Chimeric antigen receptorImmunotherapyMedicineImmunologyHerpes simplex virusCytokine release syndromePneumoniaAntigenCytomegalovirusVirusImmune systemHerpesviridaeInternal medicineViral diseaseCytomegalovirus and herpesvirus researchPolyomavirus and related diseasesHerpesvirus Infections and Treatments