Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3
Inga V. Hochheiser, Michael Pilsl, Gregor Hagelueken, Jonas Moecking, Michael Marleaux, Rebecca Brinkschulte, Eicke Latz, Christoph Engel, Matthias Geyer
Topics & Concepts
Pyrin domainChemistryNALP3DimerInflammasomeBinding siteStereochemistryPlasma protein bindingProtein structureBeta sheetBiophysicsCrystallographyBiochemistryBiologyReceptorOrganic chemistryInflammasome and immune disordersGout, Hyperuricemia, Uric AcidCalcium signaling and nucleotide metabolism