Ru(II)-Catalyzed Oxidative Olefination of Benzamides: Switchable Aza-Michael and Aza-Wacker Reaction for Synthesis of Isoindolinones
M. Kumar, Shalini Verma, Akhilesh K. Verma
Abstract
-arylbenzamides is achieved by fine-tuning between base and additive to access valuable 3-oxoisoindolinyls and 3-oxoisoindolinylidenes, respectively. Careful optimization and control experiments provides a guiding principle in the design of a proposed catalytic cycle. The copper-iminium complex acting as a precursor for the binding of Ru catalyst was isolated and confirmed by X-ray diffraction. The versatility of this catalytic system has been demonstrated by the synthesis of biologically relevant molecules.
Topics & Concepts
IminiumChemistryCatalysisMichael reactionCombinatorial chemistryCatalytic cycleWacker processTandemOxidative phosphorylationOrganic chemistryPalladiumBiochemistryComposite materialMaterials scienceCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsOxidative Organic Chemistry Reactions