Rational design of a red-light absorbing ruthenium polypyridine complex as a photosensitizer for photodynamic therapy
Alessia Fennes, Nicolás Montesdeoca, Zisis Papadopoulos, Johannes Karges
Abstract
This study details the computer-guided design, synthesis, and biological evaluation of a Ru( ii ) polypyridine complex for PDT. The complex can be excited with red light at 630 nm, showing great potential for treating large or deep-seated tumors.
Topics & Concepts
PhotosensitizerRutheniumPhotodynamic therapyPhotochemistryRed lightRational designChemistryCombinatorial chemistryMaterials scienceNanotechnologyOrganic chemistryCatalysisBiologyBotanyPhotodynamic Therapy Research StudiesNanoplatforms for cancer theranosticsLuminescence Properties of Advanced Materials