Synthesis of 1-azido-3-heteroaryl bicyclo[1.1.1]pentanes <i>via</i> azidoheteroarylation of [1.1.1]propellane
Hang Han, Bingbin Zhu, Xiaofan Du, Yu Zhu, Chuanming Yu, Xinpeng Jiang
Abstract
A novel synthesis of 1-azido-3-heteroaryl bicyclo[1.1.1]pentanes has been achieved via azidoheteroarylation of [1.1.1]propellane under mild and metal-free conditions. It provides a highly efficient route to construct azide-containing BCPs.
Topics & Concepts
PropellaneBicyclic moleculeChemistryStereochemistryClick Chemistry and ApplicationsChemical Synthesis and AnalysisRadical Photochemical Reactions