Efflux pump inhibitor combined with ofloxacin decreases MRSA biofilm formation by regulating the gene expression of NorA and quorum sensing
Xueer Lu, Guifeng Wang, Yunfeng Xie, Wenjian Tang, Biyong Liu, Jing Zhang
Abstract
Carbonyl cyanide p -nitrophenylhydrazone (2e), an efflux pump inhibitor, displayed alone or synergistic efficacy against MRSA in vitro and in vivo through regulating the gene expression of NorA and QS system.
Topics & Concepts
Quorum sensingEffluxBiofilmOfloxacinMicrobiologyChemistryGeneBiologyAntibioticsBacteriaBiochemistryCiprofloxacinGeneticsBacterial biofilms and quorum sensingAntimicrobial Peptides and ActivitiesOral microbiology and periodontitis research