Combination treatment of mannose and GalNAc conjugated small interfering RNA protects against lethal Marburg virus infection
Xin Ye, Richard Holland, Mark Wood, Chris Pasetka, Lorne Palmer, Eleni Samaridou, Kevin McClintock, Viktoriya Borisevich, Thomas W. Geisbert, Robert W. Cross, James Heyes
Topics & Concepts
Mannose receptorSmall interfering RNAVirologyMannoseConjugateEndosomeBiologyIn vitroRNA interferenceGene silencingRNACellMacrophageBiochemistryGeneMathematical analysisMathematicsViral Infections and Outbreaks ResearchPhagocytosis and Immune RegulationRNA Interference and Gene Delivery