Notch signaling inactivation by small molecule γ-secretase inhibitors restores the multiciliated cell population in the airway epithelium
Eszter K. Vladar, Koshi Kunimoto, Laura S. Rojas‐Hernandez, Jacquelyn Spano, Zachary M. Sellers, Nam Soo Joo, Riley A. Cooney, Jeffrey D. Axelrod, Carlos Milla
2023American Journal of Physiology-Lung Cellular and Molecular Physiology27 citationsDOIOpen Access PDF
Abstract
Our findings show that low-dose, short-term topical or systemic γ-secretase inhibitor treatment may lead to restoration of multiciliated cells without toxicity and potentially improve epithelial function in a wide range of chronic lung diseases.
Topics & Concepts
Notch signaling pathwayEpitheliumCell biologyRespiratory epitheliumPopulationCellAirwayBiologyCiliumChemistrySignal transductionGeneticsMedicineSurgeryEnvironmental healthNeonatal Respiratory Health ResearchNeuroscience of respiration and sleepEpigenetics and DNA Methylation