Isopedopeptins A–H: Cationic Cyclic Lipodepsipeptides from <i>Pedobacter cryoconitis</i> UP508 Targeting WHO Top-Priority Carbapenem-Resistant Bacteria
Christina Nord, Joakim Bjerketorp, Jolanta J. Levenfors, Sha Cao, Adam A. Strömstedt, Bengt Guss, Rolf Larsson, Diarmaid Hughes, Bo Öberg, Anders Broberg
Abstract
liposome system where it induced significant leakage, indicating membrane disruption as one mechanism involved in isopedopeptin antibacterial activity. Isopedopeptin B stands out as a promising candidate for further studies with the goal to develop a new antibiotic drug.
Topics & Concepts
BacteriaCationic polymerizationCarbapenemMicrobiologyChemistryBiologyAntibioticsGeneticsOrganic chemistryAntibiotic Resistance in BacteriaMicrobial Natural Products and BiosynthesisProbiotics and Fermented Foods