PCDH10 is a neuronal receptor for western equine encephalitis virus
Yan Yang, Lixin Zhao, Zhiyang Li, Su-Yun Wang, Zhi-Sheng Xu, Yan‐Yi Wang
Abstract
Western equine encephalitis virus (WEEV) is a mosquito-borne alphavirus that uses birds as reservoirs and causes severe encephalitis and death in humans and equids. 1 Currently no approved vaccines and antivirals are available and it is urgently needed to investigate the mechanisms of WEEV–host interaction for preparedness for the potential re-emerging of WEEV. The viral spike of WEEV consisting of three heterodimers of E2-E1 glycoproteins has been demonstrated to mediate cellular entry of WEEV. 2 WEEV infection causes encephalitis, but a neuronal receptor for WEEV remains enigmatic.
Topics & Concepts
BiologyVirologyVirusEncephalitisReceptorNeuroscienceGeneticsMosquito-borne diseases and controlViral Infections and VectorsVector-borne infectious diseases