Trans-ancestral dissection of urate- and gout-associated major loci SLC2A9 and ABCG2 reveals primate-specific regulatory effects
Riku Takei, Murray Cadzow, David Markie, Matt Bixley, Amanda Phipps‐Green, Tanya J. Major, Changgui Li, Hyon K. Choi, Zhiqiang Li, Hua Hu, Hui Guo, Meian He, Yongyong Shi, Lisa K. Stamp, Nicola Dalbeth, Tony R. Merriman, Wenhua Wei
Topics & Concepts
GoutBiologyHyperuricemiaGenome-wide association studyGeneticsEnhancerEpigenomicsLinkage disequilibriumEvolutionary biologyUric acidHaplotypeAlleleSingle-nucleotide polymorphismGeneEndocrinologyGenotypeTranscription factorDNA methylationGene expressionBiochemistryGout, Hyperuricemia, Uric AcidCancer-related molecular mechanisms researchPeroxisome Proliferator-Activated Receptors