KIR3DL3-HHLA2 is a human immunosuppressive pathway and a therapeutic target
Wei Yao, Xiaoxin Ren, Phillip M. Galbo, Scott Moerdler, Hao Wang, R. Alejandro Sica, Bijan Etemad-Gilbertson, Lei Shi, Liqiang Zhu, Xu-Dong Tang, Lin Qi, Mou Peng, Fangxia Guan, Deyou Zheng, Jordan M. Chinai, Xingxing Zang
Abstract
immune cells. KIR3DL3 blockade inhibited tumor growth in multiple humanized mouse models. Thus, our findings elucidated the molecular and cellular basis for the inhibitory function of KIR3DL3, demonstrating that the KIR3DL3-HHLA2 pathway is a potential immunotherapeutic target for cancer.
Topics & Concepts
BlockadeImmunotherapyImmunologyCancer researchMedicineBiologyImmune systemReceptorInternal medicineImmune Cell Function and InteractionImmune Response and InflammationT-cell and B-cell Immunology