Candida albicans Filamentation Does Not Require the cAMP-PKA Pathway <i>In Vivo</i>
Rohan S. Wakade, Juraj Kramara, Melanie Wellington, Damian J. Krysan
Abstract
, the protein kinase A pathway, is not required for filamentation during infection of the host. Our work not only demonstrates that the regulation of filamentation depends upon the specific environment C. albicans inhabits but also underscores the importance of studying these mechanisms during infection.
Topics & Concepts
Candida albicansFilamentationCorpus albicansBiologycAMP-dependent pathwayIn vivoCell biologyFungal proteinActivator (genetics)In vitroMicrobiologyGeneSaccharomyces cerevisiaeAdenylyl cyclaseSignal transductionGeneticsPhysicsLaserOpticsAntifungal resistance and susceptibilityFungal Infections and StudiesPeptidase Inhibition and Analysis