Implications of stress-induced gene expression for hematopoietic stem cell aging studies
Anna Konturek-Cieśla, Rasmus Olofzon, Shabnam Kharazi, David Bryder
Abstract
A decline in hematopoietic stem cell (HSC) function is believed to underlie hematological shortcomings with age; however, a comprehensive molecular understanding of these changes is currently lacking. Here we provide evidence that a transcriptional signature reported in several previous studies on HSC aging is linked to stress-induced changes in gene expression rather than aging. Our findings have strong implications for the design and interpretation of HSC aging studies.
Topics & Concepts
Stem cellHaematopoiesisBiologyHematopoietic stem cellGene expressionGeneFunction (biology)Cell biologyGeneticsSingle-cell and spatial transcriptomicsEpigenetics and DNA MethylationHematopoietic Stem Cell Transplantation