Litcius/Paper detail

Design, synthesis and evaluation of pyrazole bearing α-aminophosphonate derivatives as potential acetylcholinesterase inhibitors against Alzheimer’s disease

Sarfaraz Shaikh, Pratik P. Dhavan, Ganesh Pavale, M. M. V. Ramana, B. L. Jadhav

2020Bioorganic Chemistry88 citationsDOI

Topics & Concepts

ChemistryTacrineAcetylcholinesteraseRivastigmineCholinesteraseIC50PyrazoleADMEDocking (animal)PharmacologyViability assayDPPHButyrylcholinesteraseCytotoxicityStereochemistryEnzymeAntioxidantBiochemistryAchéIn vitroDonepezilDementiaMedicinePathologyDiseaseNursingCholinesterase and Neurodegenerative DiseasesPesticide Exposure and ToxicityOrganophosphorus compounds synthesis