Design, synthesis and evaluation of pyrazole bearing α-aminophosphonate derivatives as potential acetylcholinesterase inhibitors against Alzheimer’s disease
Sarfaraz Shaikh, Pratik P. Dhavan, Ganesh Pavale, M. M. V. Ramana, B. L. Jadhav
Topics & Concepts
ChemistryTacrineAcetylcholinesteraseRivastigmineCholinesteraseIC50PyrazoleADMEDocking (animal)PharmacologyViability assayDPPHButyrylcholinesteraseCytotoxicityStereochemistryEnzymeAntioxidantBiochemistryAchéIn vitroDonepezilDementiaMedicinePathologyDiseaseNursingCholinesterase and Neurodegenerative DiseasesPesticide Exposure and ToxicityOrganophosphorus compounds synthesis