Machine learning designs non-hemolytic antimicrobial peptides
Alice Capecchi, Xingguang Cai, Hippolyte Personne, Thilo Köhler, Christian van Delden, Jean‐Louis Reymond
Abstract
Machine learning models trained with experimental data for antimicrobial activity and hemolysis are shown to produce new non-hemolytic antimicrobial peptides active against multidrug-resistant bacteria.
Topics & Concepts
AntimicrobialAntimicrobial peptidesChemistryComputer scienceComputational biologyCombinatorial chemistryBiologyOrganic chemistryAntimicrobial Peptides and ActivitiesBiochemical and Structural CharacterizationImmune Response and Inflammation