Carbene-Catalyzed Enantioselective Synthesis of γ-Keto-β-silyl Esters and Amides
Yuxia Zhang, Xuan Huang, Jingcheng Guo, Chenlong Wei, Minghua Gong, Zhenqian Fu
Abstract
A variety of γ-keto-β-silyl esters and amides, most with extremely high enantioselectivities, were efficiently prepared via a carbene-catalyzed formal [4 + 2] annulation followed by ring opening with nucleophiles. The resulting compounds from this one-pot strategy can be easily converted into enantioenriched β,σ-dihydroxyl esters.
Topics & Concepts
ChemistryEnantioselective synthesisCarbeneSilylationNucleophileAnnulationCatalysisRing (chemistry)Organic chemistryCombinatorial chemistryN-Heterocyclic Carbenes in Organic and Inorganic ChemistrySynthetic Organic Chemistry MethodsCyclopropane Reaction Mechanisms