P2X7R antagonism suppresses long-lasting brain hyperexcitability following traumatic brain injury in mice
Mariana Alves, Laura de Diego-Garcia, Gloria Vegliante, Óscar Moreno, Beatriz Gutiérrez‐Gil, Pedro Ramos‐Cabrer, Meghma Mitra, Ana Fernandez Martin, Aida Menéndez‐Méndez, Yitao Wang, Nathan Ryzewski Strogulski, Meng-Juan Sun, Ciara Melia, Giorgia Conte, Sandra Plaza‐García, Igor Khalin, Xinchen Teng, Nikolaus Plesnila, Bert Klebl, Klaus Dinkel, Michael Hamacher, Anindya Bhattacharya, Marc Ceusters, James A. Palmer, David J. Loane, Jordi Llop, David C. Henshall, Tobías Engel
Abstract
Our results demonstrate the antiepileptogenic potential of P2X7R antagonism to prevent TBI-induced epilepsy and indicate that P2X7R-based PET imaging may be a useful diagnostic tool to identify people at risk of developing PTE.
Topics & Concepts
Traumatic brain injuryAntagonismNeuroscienceMedicinePharmacologyAnesthesiaPsychologyInternal medicineReceptorPsychiatryAdenosine and Purinergic SignalingNeuroscience of respiration and sleepNeonatal Respiratory Health Research