Menin inhibitors in the treatment of acute myeloid leukemia
Gerwin Huls, Carolien M. Woolthuis, Jan Jacob Schuringa
Abstract
ABSTRACT: Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy characterized by the (oligo)clonal expansion of myeloid progenitor cells. Despite advances in treatment, AML remains challenging to cure, particularly in patients with specific genetic abnormalities. Menin inhibitors have emerged as a promising therapeutic approach, targeting key genetic drivers of AML, such as KMT2A (lysine methyl transferase 2A) rearrangements and NPM1 mutations. Here, we review the clinical value of menin inhibitors, highlighting their mechanism of action, efficacy, safety, and potential to transform AML treatment.
Topics & Concepts
Myeloid leukemiaNPM1Cancer researchMyeloidMedicineAzacitidineLeukemiaMalignancyOncologyBiologyImmunologyInternal medicineGeneGeneticsDNA methylationKaryotypeGene expressionChromosomeAcute Myeloid Leukemia ResearchProtein Degradation and InhibitorsHistone Deacetylase Inhibitors Research