SPHK1 promotes HNSCC immune evasion by regulating the MMP1-PD-L1 axis
Qi Fang, Xiao Chen, Fei Cao, Pengfei Xu, Zheng Zhao, Roubin Lin, Di Wu, Wuguo Deng, Xuekui Liu
Abstract
Our study reveals a novel role for SPHK1 in mediating immune evasion in HNSCC through the regulation of the MMP1-PD-L1 axis. We identified SPHK1 and MMP1 as predictive biomarkers for the therapeutic response to PD-1 mAb and provided new therapeutic targets for patients with HNSCC.
Topics & Concepts
Immune systemMMP1Evasion (ethics)Cell biologyChemistryImmunologyBiologyBiochemistryGene expressionGeneImmune Cell Function and InteractionSignaling Pathways in Disease