Design and synthesis of new thienopyrimidine derivatives as potential anticancer agents: From cytotoxicity screening to VEGFR inhibition modeling
Feyzi Sinan Tokalı, Halil Şenol, Şeyma Ateşoğlu, Furkan Çakır, Pelin Tokalı, Fahri Akbaş
Topics & Concepts
ChemistryADMEDocking (animal)CytotoxicityMoietyStereochemistryMolecular modelSelectivityHydrogen bondCombinatorial chemistryMolecular dynamicsSulforhodamine BHydrophobic effectIn vitroStructure–activity relationshipUreaA549 cellLead compoundLigand (biochemistry)Polar surface areaEGFR inhibitorsHomology modelingDenticityPotencyBinding pocketTriazoleActive siteDrug discoverySynthesis and biological activityQuinazolinone synthesis and applicationsSynthesis and Reactions of Organic Compounds