Tuberculostearic Acid Controls Mycobacterial Membrane Compartmentalization
Malavika Prithviraj, Takehiro Kado, Jacob A. Mayfield, David C. Young, Annie D. Huang, Daisuke Motooka, Shota Nakamura, M. Sloan Siegrist, D. Branch Moody, Yasu S. Morita
Abstract
deletion mutant, we further demonstrate that tuberculostearic acid actively regulates lateral membrane heterogeneity in mycobacteria. These findings indicate the role of branched fatty acids in controlling the functions of the plasma membrane, a critical barrier for the pathogen to survive in its human host.
Topics & Concepts
Acid-fastCompartmentalization (fire protection)Fatty acidMembraneBiochemistryChemistryMicrobiologyTuberculosisBiologyMedicineEnzymePathologySputumMycobacterium research and diagnosisTuberculosis Research and EpidemiologyInfectious Diseases and Tuberculosis