Murine cerebral organoids develop network of functional neurons and hippocampal brain region identity
Francesca Ciarpella, Raluca Georgiana Zamfir, Alessandra Campanelli, Elisa Ren, Giulia Pedrotti, Emanuela Bottani, Andrea Borioli, Davide Caron, Marzia Di Chio, Sissi Dolci, Annika Ahtiainen, Giorgio Malpeli, Giovanni Malerba, Rita Bardoni, Guido Francesco Fumagalli, Jari Hyttinen, Francesco Bifari, Gemma Palazzolo, Gabriella Panuccio, Giulia Curia, Ilaria Decimo
Abstract
Murine embryonic NSCs are able to self-organize into brain organoids Murine brain organoids mature in 32 days, showing dorsal forebrain identity Brain organoids develop 3D network of functional neurons WNT3a supplementation induces specific hippocampal brain region identity
Topics & Concepts
OrganoidHippocampal formationInduced pluripotent stem cellNeuroscienceEmbryonic stem cellForebrainDrug discoveryHuman brainPhenotypic screeningBiologyNeural stem cellStem cellPhenotypeComputational biologyCell biologyBioinformaticsCentral nervous systemGeneBiochemistryPluripotent Stem Cells Research3D Printing in Biomedical ResearchNeuroscience and Neural Engineering