Instability of sputum molecular phenotypes in U-BIOPRED severe asthma
Nazanin Zounemat Kermani, Stelios Pavlidis, Jiaxing Xie, Kai Sun, Matthew J. Loza, Fred Baribaud, Stephen J. Fowler, Dominick Shaw, Louise Fleming, Peter Howarth, Ana R. Sousa, Julie Corfield, Charles Auffray, Bertrand De Meulder, Peter J. Sterk, Yike Guo, Mohib Uddin, Ratko Djukanović, Ian M. Adcock, Kian Fan Chung
Abstract
<b>At 1 year, 45% of severe asthma change molecular phenotype as determined by sputum transcriptomic analysis. Together with concomitant shift in sputum granulocytic markers, this may indicate variability of driving mechanisms in this unstable group.</b>https://bit.ly/35aj489
Topics & Concepts
SputumPhenotypeAsthmaConcomitantTranscriptomeMedicineImmunologyInternal medicineBiologyGeneticsGenePathologyGene expressionTuberculosisAsthma and respiratory diseasesIL-33, ST2, and ILC PathwaysHelicobacter pylori-related gastroenterology studies