More than 185 CAG repeats: a point of no return in Huntington’s disease biology
Jillian Belgrad, Anastasia Khvorova
Abstract
This scientific commentary refers to ‘A CAG repeat threshold for therapeutics targeting somatic instability in Huntington’s disease’ by Aldous et al. (https://doi.org/10.1093/brain/awae063).
Topics & Concepts
Huntington's diseaseDiseaseTrinucleotide repeat expansionSomatic cellNeuroscienceGeneticsPoint mutationBiologyPsychologyMutationMedicineInternal medicineGeneAlleleGenetic Neurodegenerative DiseasesMitochondrial Function and PathologyNeurological disorders and treatments